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pentobarbital will decrease the level or influence of cinacalcet by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.pentobarbital will minimize the extent or outcome of cobimetinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Steer clear of coadministration. Sturdy or average CYP3A ind